Exploring the effect and mechanism of fucoidan on liver cancer depending on network pharmacology and experimental verification
Fucoidan exerts its anti-liver cancer effect primarily by downregulating mRNA expression levels of target genes including AKT1, PI3K, PIK3R1, PIK3CA and other targets, inhibition of PI3K/Akt signaling pathway activation, and suppressing HepG2 cell proliferation.
Authors
- Ihsan Ullah (ORCID: https://orcid.org/0000-0003-1441-2105)
- Xinyue Liu (ORCID: https://orcid.org/0000-0002-0934-4155)
- Xinghua Li (ORCID: https://orcid.org/0000-0002-2971-159X)
- Cheng‐Yu Yang (ORCID: https://orcid.org/0000-0002-5196-4032)
- Liwei Wang (ORCID: https://orcid.org/0000-0003-4990-9445)
- Chen Feng (ORCID: https://orcid.org/0000-0003-1144-0047)
- Qi Liu
Institutions
- Shanxi Medical University (CN)
- Shanxi University (CN)
- Changzhi Medical College (CN)
- Shanxi Provincial Cancer Hospital (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Frontiers in Chemistry
- Published
- 2025-07-16
- DOI
- https://doi.org/10.3389/fchem.2025.1638785
- Citations
- 1
- Primary Topic
- Seaweed-derived Bioactive Compounds
- Type
- article
- Field-Weighted Citation Impact
- 2.27