Anti-podocin Enzyme-Linked Immunosorbent Assay Guides Immunotherapy in Steroid-Resistant Nephrotic Syndrome
Steroid-resistant nephrotic syndrome (SRNS) has diverse causes, yet treatment often relies on high-dose corticosteroids, calcineurin inhibitors (CNI), mycophenolate mofetil (MMF), cyclophosphamide, or rituximab (RTX) in a trial-and-error fashion, without identifying the underlying etiology1. Recently, autoantibodies against slit diaphragm proteins—nephrin, podocin, and Kirrel1—have been found in patients responsive to second-line immunosuppression, but not in genetic SRNS2-6. However, diagnostic tools for detecting autoimmune podocytopathies (APs) remain limited.
Authors
- Elisa Buti
- Maria Elena Melica (ORCID: https://orcid.org/0000-0002-4599-4083)
- Letizia De Chiara (ORCID: https://orcid.org/0000-0002-8548-2031)
- Benedetta Mazzinghi (ORCID: https://orcid.org/0000-0003-2809-5622)
- Samantha Innocenti
- Viviana Palazzo (ORCID: https://orcid.org/0000-0001-7800-8094)
- Giulia Antonelli (ORCID: https://orcid.org/0000-0002-2555-2130)
- Luigi Cirillo (ORCID: https://orcid.org/0000-0002-0440-7356)
- Paola Romagnani (ORCID: https://orcid.org/0000-0002-1774-8088)
- Carolina Conte (ORCID: https://orcid.org/0000-0002-7679-2935)
- Elena Lazzeri (ORCID: https://orcid.org/0000-0002-9505-2115)
- Carmela Errichiello (ORCID: https://orcid.org/0009-0006-8803-5698)
- Andrea La Tessa (ORCID: https://orcid.org/0000-0002-6248-2864)
- Samuela Landini (ORCID: https://orcid.org/0000-0001-7423-0325)
- Laura Lasagni (ORCID: https://orcid.org/0000-0001-6553-9160)
- Anna Julie Peired (ORCID: https://orcid.org/0000-0001-9732-1369)
- Giulia Sansavini
- Francesca Becherucci (ORCID: https://orcid.org/0000-0002-1011-7291)
- Maria Lucia Angelotti (ORCID: https://orcid.org/0000-0003-3988-7852)
- Valentina Raglianti (ORCID: https://orcid.org/0000-0002-6610-3251)
- Hans‐Joachim Anders (ORCID: https://orcid.org/0000-0003-2434-2956)
- Anna Maria Buccoliero (ORCID: https://orcid.org/0000-0002-4993-0765)
Institutions
- Meyer Children's Hospital (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Florence (IT)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Kidney International Reports
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1016/j.ekir.2025.07.003
- Citations
- 1
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- European Commission
- Regione Toscana