Frailty Index-laboratory and lymphocyte subset patterns in predicting 28-day mortality among elderly sepsis patients: a multicenter observational cohort study
FI-lab independently predicts mortality in elderly sepsis patients and correlates with lymphocyte abnormalities. When comprehensive immune assessment is unavailable, lymphocyte trajectory patterns offer a practical approach for risk stratification.
Authors
- Yawen Xie (ORCID: https://orcid.org/0000-0002-3621-2529)
- Guoyu Zhao
- Zhigang Chang (ORCID: https://orcid.org/0000-0002-3125-0040)
- Na Cui (ORCID: https://orcid.org/0000-0003-1128-9228)
- Jiahui Zhang
- Hao Wang (ORCID: https://orcid.org/0000-0001-6071-4169)
- Yuefu Wang (ORCID: https://orcid.org/0000-0003-4776-9266)
- Dongkai Li (ORCID: https://orcid.org/0000-0002-4487-0927)
- Xiao Li (ORCID: https://orcid.org/0000-0003-1992-3529)
- Zhan Shi (ORCID: https://orcid.org/0000-0002-6367-8041)
- Jiatong Hou
- Xianli Lei
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- Peking Union Medical College Hospital (CN)
- Beijing Jishuitan Hospital (CN)
- Beijing Hospital (CN)
- Beijing Shijitan Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-07-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1624655
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chinese Academy of Medical Sciences
- Peking Union Medical College Hospital