High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes
The findings supported our hypothesis that both aging and the mutation (loss of LEPR in somatotropes) would render these mice more sensitive to a HFD as more pituitary cell types were affected transcriptionally. Collectively, these findings indicate that HFD and/or obese state may compromise pituitary plasticity by down-regulating translational processes and reducing expression in cells that may have multipotential functions. The oxidative stress of a HFD may thus limit the expression of pituitary progenitor cells.
Authors
- Anessa Haney
- Gwen V. Childs (ORCID: https://orcid.org/0000-0003-3764-1373)
- Angela K. Odle (ORCID: https://orcid.org/0000-0001-5017-9676)
- Melanie C MacNicol (ORCID: https://orcid.org/0000-0001-6927-2475)
- Ashley Herdman
- Angus M. MacNicol (ORCID: https://orcid.org/0000-0003-4812-9519)
- Tiffany K. Miles
- Alex Lagasse
- Stephanie D. Byrum
- Victoria G Ortega
Institutions
- Arkansas Children's Hospital (US)
- University of Arkansas for Medical Sciences (US)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-07-16
- DOI
- https://doi.org/10.3389/fendo.2025.1617109
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- National Institutes of Health
- Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences
- National Institute of General Medical Sciences