Exploratory study of the effect of DHA supplementation on blood fatty acids and inflammatory markers in children with MIS-C
This pilot study is the first to explore the potential effects of DHA supplementation in children with MIS-C. DHA was associated with improvements in the blood fatty acid profile, which persisted beyond the supplementation period, and showed a trend toward normalization of selected biochemical parameters. Further adequately powered, controlled studies are needed to confirm these observations and to evaluate the potential role of early n-3 PUFA supplementation during the stable and recovery phases in critically ill pediatric patients.
Authors
- Sara Vizzuso (ORCID: https://orcid.org/0000-0002-3001-0387)
- Patrizia Risé (ORCID: https://orcid.org/0000-0002-7564-3508)
- Laura M. Fiori (ORCID: https://orcid.org/0000-0002-6840-471X)
- Giulia Fiore (ORCID: https://orcid.org/0000-0002-6100-5687)
- Angelo Sala (ORCID: https://orcid.org/0000-0001-9290-0257)
- Elisabetta Di Profio (ORCID: https://orcid.org/0000-0002-6155-0546)
- Savina Mannarino (ORCID: https://orcid.org/0000-0001-9099-1845)
- Alice Bonomi (ORCID: https://orcid.org/0000-0001-5409-0791)
- Enza D’Auria (ORCID: https://orcid.org/0000-0003-2750-5810)
- Dario Dilillo (ORCID: https://orcid.org/0000-0002-5978-6146)
- Gianvincenzo Zuccotti (ORCID: https://orcid.org/0000-0002-2795-9874)
- Valeria Calcaterra (ORCID: https://orcid.org/0000-0002-2137-5974)
- Elvira Verduci (ORCID: https://orcid.org/0000-0003-2111-3111)
- Elena Zoia
Institutions
- University of Milan (IT)
- Centro Cardiologico Monzino (IT)
- Ospedale dei Bambini Vittore Buzzi (IT)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-07-16
- DOI
- https://doi.org/10.3389/fnut.2025.1597868
- Primary Topic
- Kawasaki Disease and Coronary Complications
- Type
- article
- Field-Weighted Citation Impact
- 0.00