Loss of p21 does not protect against premature ovarian insufficiency caused by alkylating agents
These results demonstrated that p21 is dispensable for POI caused by alkylating agents, suggesting that targeting p21 alone may not mitigate ovarian aging caused by alkylating agents.
Authors
- Xiuliang Dai (ORCID: https://orcid.org/0009-0008-2323-6143)
- Pingping Xue (ORCID: https://orcid.org/0000-0002-8248-9473)
- Yongli Han (ORCID: https://orcid.org/0000-0002-2129-7507)
- Jiaming Song (ORCID: https://orcid.org/0009-0006-0399-2422)
- Pengfei Liu (ORCID: https://orcid.org/0000-0001-6070-100X)
- Yufeng Wang (ORCID: https://orcid.org/0000-0002-1869-3875)
- Li Chen (ORCID: https://orcid.org/0009-0007-6683-0102)
- Qin Wan (ORCID: https://orcid.org/0000-0001-7688-5392)
- Xiaohui Lu (ORCID: https://orcid.org/0000-0002-5732-962X)
Institutions
- China Animal Disease Control Center (CN)
- Changzhou Vocational Institute of Engineering (CN)
- Changzhou No.2 People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-07-16
- DOI
- https://doi.org/10.3389/fendo.2025.1616965
- Citations
- 1
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 1.88