SIRT7 ameliorates Th17/Treg imbalance by desuccinylation of STAT3 to improve immune thrombocytopenia
SIRT7 mitigates ITP progression by maintaining Th17/Treg equilibrium through desuccinylation of STAT3. These findings highlight SIRT7 as a potential therapeutic target for ITP treatment, offering novel insights into the epigenetic regulation of immune dysregulation in autoimmune diseases.
Authors
- Jiao Ge
- Yan Liu (ORCID: https://orcid.org/0000-0003-3905-1780)
- Fajuan Tang
- Xiaoyan Zhang (ORCID: https://orcid.org/0000-0002-8900-3229)
Institutions
- Sichuan University (CN)
- West China Second University Hospital of Sichuan University (CN)
Publication Details
- Journal
- Clinical & Translational Immunology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1002/cti2.70048
- Citations
- 4
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 7.08