Triple reversal phenomenon in EGFR-mutant lung adenocarcinoma with prostate metastasis following hepatocellular carcinoma: a rare Case Report with diagnostic and therapeutic implications

This case illustrates a rare instance of prostatic metastasis from EGFR-mutant lung adenocarcinoma and emphasizes the critical role of repeat biopsy, molecular profiling, and multidisciplinary evaluation in atypical metastatic presentations. The diagnostic process involved a "triple reversal" phenomenon, revising initial misdiagnoses of recurrent HCC and primary prostate cancer to metastatic NSCLC. Targeted therapy with osimertinib was effective, underscoring the importance of precision oncology in managing complex metastatic disease.