Characterization of lactylation modification subtypes and the promoting role of CCL20 in hepatocellular carcinoma progression
This study established a lactylation modification-based prognostic model that accurately forecasts outcomes in HCC patients. This risk score showed a significant correlation with glucose metabolism and reflected immune cell infiltration patterns. The core model gene, CCL20, promotes HCC cell proliferation and migration, supporting its potential as a valuable prognostic biomarker and a therapeutic target for HCC.
Authors
- Xi Yan (ORCID: https://orcid.org/0000-0002-8048-9461)
- Lihong Wu (ORCID: https://orcid.org/0000-0002-1903-6981)
- Jing Wei (ORCID: https://orcid.org/0000-0002-2371-6111)
- Shuang Bai (ORCID: https://orcid.org/0000-0001-6404-7703)
- Jun Wang (ORCID: https://orcid.org/0000-0001-5895-1333)
- Yang Liu (ORCID: https://orcid.org/0000-0001-7714-9194)
- Fei Tian (ORCID: https://orcid.org/0000-0003-4106-2841)
- Xiang-Xu Wang
Institutions
- The Fourth People's Hospital (CN)
- Xi’an Children’s Hospital (CN)
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-07-16
- DOI
- https://doi.org/10.3389/fgene.2025.1605055
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52