Plasma calprotectin as a severity biomarker in pediatric invasive Streptococcus pyogenes infections: insights from a multicenter immune profiling study during an outbreak
Pediatric iGAS is characterized by a complex immune landscape involving a combination of vascular and immune response mediators. Plasma calprotectin levels emerge as a promising severity biomarker, potentially aiding in the early identification of high-risk patients.
Authors
- Roberto Lozano‐Rodríguez (ORCID: https://orcid.org/0000-0003-0093-9707)
- Rosa del Campo (ORCID: https://orcid.org/0000-0003-1147-7923)
- Cristina Calvo (ORCID: https://orcid.org/0000-0002-6503-3423)
- Rafael Cantón (ORCID: https://orcid.org/0000-0003-1675-3173)
- Andrea López-Suárez
- Eduardo López‐Collazo (ORCID: https://orcid.org/0000-0003-1957-877X)
- Antonio Jiménez
- José Avendaño‐Ortiz (ORCID: https://orcid.org/0000-0003-2774-1821)
- Jesús Oteo (ORCID: https://orcid.org/0000-0003-3327-8263)
- Beatriz Jiménez (ORCID: https://orcid.org/0000-0003-4593-6075)
- Jesús Saavedra‐Lozano (ORCID: https://orcid.org/0000-0001-5971-011X)
- David Aguilera‐Alonso (ORCID: https://orcid.org/0000-0003-1017-2386)
- Victoria Rello-Saltor
- C Rodríguez
Institutions
- Universitat Autònoma de Barcelona (ES)
- Hospital Universitario La Paz (ES)
- Instituto de Salud Carlos III (ES)
- Hospital General Universitario Gregorio Marañón (ES)
- Sociedad Española de Medicina Interna (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (ES)
- Marqués de Valdecilla University Hospital (ES)
- Hospital La Paz Institute for Health Research (ES)
- Instituto Ramón y Cajal de Investigación Sanitaria (ES)
- Vall d'Hebron Hospital Universitari (ES)
- Hospital Universitario Fundación Jiménez Díaz (ES)
- Hospital Universitario Ramón y Cajal (ES)
- Universidad Autónoma de Madrid (ES)
Publication Details
- Journal
- Journal of Microbiology Immunology and Infection
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1016/j.jmii.2025.07.008
- Citations
- 1
- Primary Topic
- Streptococcal Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.88