Prognostic impact and clinical management of pT4N0 colon cancer: data from a large, multicenter, international, real-world dataset
T4 was confirmed to be a poor prognostic factor. Adjuvant chemotherapy provided a large benefit, with a significant reduction in risk of recurrence and death. The benefit was proportional to its duration, and oxaliplatin-based chemotherapy may be better than monotherapy.
Authors
- Lorenzo Antonuzzo (ORCID: https://orcid.org/0000-0003-3349-5604)
- Valentina Daprà (ORCID: https://orcid.org/0009-0001-3319-840X)
- Stefano Tamberi (ORCID: https://orcid.org/0000-0002-7087-9116)
- Maria Alessandra Calegari (ORCID: https://orcid.org/0000-0001-6856-2593)
- Gianluca Mauri (ORCID: https://orcid.org/0000-0002-7646-0973)
- Annalice Gandini (ORCID: https://orcid.org/0000-0003-2873-5108)
- Antonino Spinelli (ORCID: https://orcid.org/0000-0002-1493-1768)
- Giulia Caira
- Lisa Salvatore (ORCID: https://orcid.org/0000-0003-3864-0719)
- S. Siena
- Erica Bonazzina (ORCID: https://orcid.org/0000-0002-0660-5583)
- Alberto Puccini (ORCID: https://orcid.org/0000-0002-2492-4043)
- Vincenzo Formica (ORCID: https://orcid.org/0000-0002-5380-3144)
- M.L. Iaia
- Massimo Costantini (ORCID: https://orcid.org/0000-0002-5293-7079)
- Alessandra Boccaccino (ORCID: https://orcid.org/0000-0001-7242-4396)
- Federica Zoratto (ORCID: https://orcid.org/0000-0001-8387-1968)
- Francesco Schietroma (ORCID: https://orcid.org/0009-0009-9669-8602)
- Carlo Signorelli (ORCID: https://orcid.org/0000-0001-9710-4962)
- Daniele Rossini (ORCID: https://orcid.org/0009-0000-3777-8471)
- G. Tortora
- Michela Rofei
- J. Taieb
- Armando Santoro (ORCID: https://orcid.org/0000-0003-1709-9492)
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Humanitas University (IT)
- Université Paris Cité (FR)
- Agostino Gemelli University Polyclinic (IT)
- Ospedale "Santa Maria delle Croci" di Ravenna (IT)
- Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT)
- Ospedale di Cattinara (IT)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Européen Georges-Pompidou (FR)
- Azienda Sanitaria Locale Viterbo (IT)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Policlinico Tor Vergata (IT)
- Ospedale Santa Maria Goretti (IT)
- Ospedale Policlinico San Martino (IT)
- IRCCS Humanitas Research Hospital (IT)
- University of Florence (IT)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1016/j.esmoop.2025.105496
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Associazione Italiana per la Ricerca sul Cancro