Influence of Preoperative Diagnosis of Nutritional Disorders on Short-Term Outcomes After Hip Arthroplasty: A Cohort Study of Older Adults
<b>Background</b>: Nutritional disorders may affect short-term recovery after major orthopaedic surgery, but evidence is lacking. This study assessed whether and how different nutritional disorders diagnosed at admission could influence early recovery after hip replacement. <b>Methods</b>: A prospective analytical study was designed to include 60 patients scheduled for elective primary hip replacement and assess their nutritional status to diagnose 5 malnutrition phenotypes: undernutrition, sarcopenia, obesity, sarcopenic obesity, and sarcopenic undernutrition. Outcome measures were 24 h change in neutrophils, 72 h change in haemoglobin, and 10-day gait speed regain. <b>Results</b>: Haemoglobin reached the nadir at day 2-3 and partially recovered by day 10 in all patients, with sarcopenia and undernutrition being the strongest predictors of the postoperative drop (-2.37 g∙dL<sup>-1</sup> and -0.80 g∙dL<sup>-1</sup>, <i>p</i> < 0.05). Neutrophils peaked immediately after surgery and returned to baseline levels at discharge, with sarcopenic undernutrition displaying a blunted response after surgery (-16.20%, <i>p</i> < 0.01). Undernutrition was found to be the most influential preoperative variable on gait speed recovery, but with a marginal effect. None of the patients covered the reference energy and protein needs through diet in the 10 postoperative days. <b>Conclusions</b>: In this cohort, nutritional disorders with reduced body function and reserves (sarcopenia and undernutrition) grounded a greater vulnerability to surgery in terms of early stress response and short-term recovery. This calls for both advanced planning of nutritional prehabilitation strategies for these conditions and adequate postoperative nutritional support.
Authors
- Paola De Luca (ORCID: https://orcid.org/0000-0001-9810-8818)
- Stefano Petrillo (ORCID: https://orcid.org/0000-0003-0843-2273)
- Matteo Briguglio (ORCID: https://orcid.org/0000-0003-0801-2359)
- Paolo Sirtori (ORCID: https://orcid.org/0000-0001-8740-9957)
- Giuseppe Maria Peretti (ORCID: https://orcid.org/0000-0001-9341-7187)
- Giovanni Lombardi (ORCID: https://orcid.org/0000-0002-8365-985X)
- Giuseppe Banfi (ORCID: https://orcid.org/0000-0001-9578-5338)
- Thomas W. Wainwright (ORCID: https://orcid.org/0000-0001-7860-2990)
- Marialetizia Latella (ORCID: https://orcid.org/0000-0001-7932-0602)
- Laura Mangiavini (ORCID: https://orcid.org/0000-0003-1892-1249)
- Elena De Vecchi (ORCID: https://orcid.org/0000-0001-9781-8607)
- Manuela Geroldi
Institutions
- Dorset HealthCare University NHS Foundation Trust (GB)
- Vita-Salute San Raffaele University (IT)
- University of Milan (IT)
- Istituto Clinico Sant'Ambrogio (IT)
- IRCCS Ospedale Galeazzi - Sant'Ambrogio (IT)
- Orthopaedic Research (GB)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Lanzhou University (CN)
- Bournemouth University (GB)
Publication Details
- Journal
- Nutrients
- Published
- 2025-07-14
- DOI
- https://doi.org/10.3390/nu17142319
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00