Influence of Preoperative Diagnosis of Nutritional Disorders on Short-Term Outcomes After Hip Arthroplasty: A Cohort Study of Older Adults

<b>Background</b>: Nutritional disorders may affect short-term recovery after major orthopaedic surgery, but evidence is lacking. This study assessed whether and how different nutritional disorders diagnosed at admission could influence early recovery after hip replacement. <b>Methods</b>: A prospective analytical study was designed to include 60 patients scheduled for elective primary hip replacement and assess their nutritional status to diagnose 5 malnutrition phenotypes: undernutrition, sarcopenia, obesity, sarcopenic obesity, and sarcopenic undernutrition. Outcome measures were 24 h change in neutrophils, 72 h change in haemoglobin, and 10-day gait speed regain. <b>Results</b>: Haemoglobin reached the nadir at day 2-3 and partially recovered by day 10 in all patients, with sarcopenia and undernutrition being the strongest predictors of the postoperative drop (-2.37 g∙dL<sup>-1</sup> and -0.80 g∙dL<sup>-1</sup>, <i>p</i> < 0.05). Neutrophils peaked immediately after surgery and returned to baseline levels at discharge, with sarcopenic undernutrition displaying a blunted response after surgery (-16.20%, <i>p</i> < 0.01). Undernutrition was found to be the most influential preoperative variable on gait speed recovery, but with a marginal effect. None of the patients covered the reference energy and protein needs through diet in the 10 postoperative days. <b>Conclusions</b>: In this cohort, nutritional disorders with reduced body function and reserves (sarcopenia and undernutrition) grounded a greater vulnerability to surgery in terms of early stress response and short-term recovery. This calls for both advanced planning of nutritional prehabilitation strategies for these conditions and adequate postoperative nutritional support.

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Publication Details

Journal
Nutrients
Published
2025-07-14
DOI
https://doi.org/10.3390/nu17142319
Primary Topic
Nutrition and Health in Aging
Type
article
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0.00
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article

Influence of Preoperative Diagnosis of Nutritional Disorders on Short-Term Outcomes After Hip Arthroplasty: A Cohort Study of Older Adults

Paola De Luca, Stefano Petrillo, Matteo Briguglio, Paolo Sirtori et al.
Nutrients
Nutrition and Health in Aging
article

Influence of Preoperative Diagnosis of Nutritional Disorders on Short-Term Outcomes After Hip Arthroplasty: A Cohort Study of Older Adults

Paola De Luca, Stefano Petrillo, Matteo Briguglio, Paolo Sirtori, Giuseppe Maria Peretti, Giovanni Lombardi, Giuseppe Banfi, Thomas W. Wainwright, Marialetizia Latella, Laura Mangiavini, Elena De Vecchi, Manuela Geroldi
article en

Abstract

<b>Background</b>: Nutritional disorders may affect short-term recovery after major orthopaedic surgery, but evidence is lacking. This study assessed whether and how different nutritional disorders diagnosed at admission could influence early recovery after hip replacement. <b>Methods</b>: A prospective analytical study was designed to include 60 patients scheduled for elective primary hip replacement and assess their nutritional status to diagnose 5 malnutrition phenotypes: undernutrition, sarcopenia, obesity, sarcopenic obesity, and sarcopenic undernutrition. Outcome measures were 24 h change in neutrophils, 72 h change in haemoglobin, and 10-day gait speed regain. <b>Results</b>: Haemoglobin reached the nadir at day 2-3 and partially recovered by day 10 in all patients, with sarcopenia and undernutrition being the strongest predictors of the postoperative drop (-2.37 g∙dL<sup>-1</sup> and -0.80 g∙dL<sup>-1</sup>, <i>p</i> < 0.05). Neutrophils peaked immediately after surgery and returned to baseline levels at discharge, with sarcopenic undernutrition displaying a blunted response after surgery (-16.20%, <i>p</i> < 0.01). Undernutrition was found to be the most influential preoperative variable on gait speed recovery, but with a marginal effect. None of the patients covered the reference energy and protein needs through diet in the 10 postoperative days. <b>Conclusions</b>: In this cohort, nutritional disorders with reduced body function and reserves (sarcopenia and undernutrition) grounded a greater vulnerability to surgery in terms of early stress response and short-term recovery. This calls for both advanced planning of nutritional prehabilitation strategies for these conditions and adequate postoperative nutritional support.

NutrientsVol. 17(14)
Dorset HealthCare University NHS Foundation Trust (GB), Vita-Salute San Raffaele University (IT), University of Milan (IT), Istituto Clinico Sant'Ambrogio (IT), IRCCS Ospedale Galeazzi - Sant'Ambrogio (IT), Orthopaedic Research (GB), Istituti di Ricovero e Cura a Carattere Scientifico (IT), Lanzhou University (CN), Bournemouth University (GB)
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Openalex Percentile: Top 77%
Nutrition and Health in Aging
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