ANALYSIS OF OXIDATIVE STRESS INDICATORS IN PERINATAL PATHOLOGY IN PREMATURE INFANTS

The balance between free radical oxidation mechanisms and the antioxidant defense system is an important condition for the body's adaptation to new conditions of existence after birth. The effect of hypoxia in conditions of morpho-functional immaturity in premature babies (PB) is the cause of the development of intracellular metabolism disorders, which causes dysmetabolic distress – a syndrome that is a predictor of the development of severe forms of somatic dysfunction in the postnatal period. The formation of disorders of physical and neuropsychological development, as well as the development of functional and chronic pathology in children in later years of life, is a consequence of hypoxic damage to the body after birth.The aim of the study was to investigate the diagnostic value of markers of free radical oxidation and the body's antioxidant defense system in premature infants with perinatal pathology under conditions of birth stress and hypoxia based on the study of umbilical cord blood.Material and methods. The main group consisted of 38 children born at 32-34 weeks of gestation who had clinical manifestations of severe perinatal pathology; the comparison group consisted of 27 conditionally healthy PNDs with a gestational age at birth of 35 to 37 weeks, whose additional examination results served as controls for comparison with the results of the newborns in the main study group. The exclusion criteria were: gestational age of 37 full weeks or more at birth, body weight of 2500 g or more, signs of intrauterine infection and congenital malformations. The characteristics of children's adaptation after birth and pathological conditions of the early neonatal period were analysed, taking into account the leading symptoms of diseases. The characteristics of children's adaptation after birth and pathological conditions of the early neonatal period were analysed, taking into account the leading symptoms of diseases. Additional research methods included a set of indicators of VRO and AOSZ, namely: malondialdehyde and oxidative modification of proteins; ceruloplasmin, catalase, HS groups, glutathione peroxidase, glutathione reductase, glutathione-S-transferase, and glucose-6-phosphate dehydrogenase activity. The examination was conducted in compliance with the basic provisions on human rights and biomedicine. Statistical processing of the obtained data was performed using licensed software Statistica (StatSoft Inc., Version 7), Microsoft Excel (AtteStat, Version 12.5) and MedCalc Software (Version 16.1).