ACUTE CORONARY SYNDROME: PROSPECTS OF STUDYING HRTO/HRTS INDICATORS AND DIGITALIZED ECG MARKERS IN PRECISION CARDIOLOGY. CLINICAL CASE

Acute coronary syndrome is one of the leading causes of reduced life expectancy and quality of life. With the advancement of computer technologies, new opportunities have emerged for calculating additional diagnostic markers, including the first derivative of the T wave and heart rate turbulence parameters, through the implementation of innovative analytical methods. These developments allow for an expanded and refined range of diagnostic approaches in the assessment of acute coronary syndrome.The aim of the study is to evaluate the effectiveness of investigating novel diagnostic and prognostic markers derived from digitilized ECG analysis, along with the implementation of innovative heart rate turbulence assessment methods in patients with NSTEMI, illustrated through a clinical case.Results. Based on the digitilized ECG data, a decrease of maximum speed ratio (MSR) was detected in the area of potential ischemia, with a value of 0.87, indicating a possible development of NSTEMI. An elevated MSR in lead V2 was observed, reaching 2.47, suggestive of hypertrophic changes of the left ventricle. The HRTO value was -2.57%, which is within the normal range, whereas the HRTS was 1.57 ms/RR, which is below the normal threshold of >2.5 ms/RR.Conclusions. The implementation of additional parameters from digitized ECG and heart rate turbulence analysis represents a promising approach to enhancing the diagnostic toolkit for NSTEMI. This clinical case highlights the effectiveness of evaluating MSR in differentiated ECG, where its changes indicated the development of NSTEMI and the presence of left ventricular hypertrophy. Additionally, a reduced HRTS value, identified through heart rate turbulence assessment, was found to correlate with an unfavorable cardiovascular prognosis.