Nanozymes in Ocular Disease Therapy: Research and Advancements

Nanozymes, a class of nanomaterials exhibiting enzyme-like catalytic activity, possess unique physicochemical properties and excellent biocompatibility, rendering them highly promising in the biomedical field. Recently, their application in ocular disease therapy has garnered significant attention. This review summarizes the recent advancements in the application of various types of nanozymes for ocular disease treatment, specifically focusing on catalase-mimicking, superoxide dismutase-mimicking, peroxidase-mimicking, and metal-organic framework (MOF) nanozymes. It also discusses the integration of nanozymes with drug delivery systems to enhance their therapeutic efficacy. Furthermore, this review addresses the current challenges hindering the clinical translation of nanozymes in ophthalmology and provides insights into future research directions.