Theoretical investigation of covalent inhibitors targeting ricin
Covalent binders targeting Ser176 in the RTA active site can function as dual-site ligands by also engaging the secondary site.
Authors
- Marcelo Santos (ORCID: https://orcid.org/0000-0003-2065-6579)
- Fernanda Botelho
- Steven R. LaPlante (ORCID: https://orcid.org/0000-0003-2835-5789)
- Mariana Magalhães (ORCID: https://orcid.org/0000-0003-1392-4176)
- Tanos C. C. França (ORCID: https://orcid.org/0000-0002-6048-8103)
- Al Ajamian
Institutions
- Institut National de la Recherche Scientifique (CA)
- Military Institute of Engineering (BR)
- University of Hradec Králové (CZ)
Publication Details
- Journal
- New Journal of Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5nj01464f
- Primary Topic
- Toxin Mechanisms and Immunotoxins
- Type
- article
- Field-Weighted Citation Impact
- 0.00