An Atypical Presentation of Guillain-Barre Syndrome with Descending Paralysis: A Case Report

The patient had an atypical presentation of Guillain-Barre syndrome (GBS) with descending muscle weakness and paralysis that started at the upper extremities and progressed to the lower extremities in contrast to a typical ascending infection that usually starts at the lower extremities. Hyporeflexia of deep tendon reflexes of the affected extremities was also present. About 2 weeks prior he had a preceding infection of cytomegalovirus with no other significant past medical history. He was admitted to the ICU for 4 days due to his rapidly deteriorating state with chest pain and shortness of breath. MRI of the spine showed nerve root enhancement. Due to suspicion of GBS, patient was started on a course of IVIG to be completed over 5 days and plasmapheresis was to be completed over 14 days. Once hemodynamically stable patient was transferred to an acute inpatient rehab facility for further treatment. After 30 days of acute inpatient rehab he was later discharged with improvement of symptoms.