MECHANISMS OF GUT MICROBIOME AND CARBOHYDRATE METABOLISM REGULATION IN WOMEN WITH METABOLIC SYNDROME THROUGH SKELETAL MUSCLE ACTIVITY

Connecon of the publicaon with planned research works.The work is part of SRW Naonal University of Physical Educaon and Sports of Ukraine "The inuence of exogenous and endogenous factors on the course of adapve reacons of the body to physical loads of varying intensity", state registraon number 012U108187. Introduction.Metabolic syndrome (MS) is a cluster of metabolic disorders, including insulin resistance, atherogenic dyslipidemia, central obesity, and hypertension, pathophysiologically inducing a chronic proinflammatory state [1].Insulin resistance is a causal factor in the etiology of diabetes mellitus, complications of which provoke dysfunction in the kidneys, retina, cardiovascular system, neurons, and liver, which is a potentially disabling condition [2].Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia, insulin resistance, and insufficient insulin secretion.Studies [3] show that changes in the gut microbiome determine the onset of T2DM through changes in glucose metabolism and abnormal production of shortchain fatty acids (SCFAs) such as acetic acid, propionic acid, and butyric acid, which are directly related to the development of dysbiosis [4].