MORPHOMETRIC CHARACTERISTICS OF THE STATE OF THE HEMOMICROCIRCULATORY BED OF THE VASCULAR LAYER OF THE EYEBALL AT 6 WEEKS OF DIABETES MELLITUS (EXPERIMENTAL INVESTIGATION)

According to the denion of the WHO expert group, diabetes mellitus, as a pandemic of the 21st century, occupies a leading place among the causes of disability of the able-bodied populaon of economically developed countries.In view of this, scienc research aimed at a thorough study of structural and ultrastructural changes in ssues and organs in experimental models has gained priority.Laboratory rats of the Wistar line were chosen as the laer.The presented experimental study is aimed at nding morphometric changes in the hemomicrocirculatory bed of the choroid of the eyeball of rats under condions of arcially induced diabetes mellitus with streptozotocin in the period from 6 weeks from the onset of the disease.Considering the predominant lesion of the vascular link, we focused on the morphometric analysis of the angioarchitectonics of the eyeball, which is the basis for assessing the degree of pathological changes in its vascularizaon under condions of diabetes mellitus.The experiment proved that compensatory mechanisms are not able to reduce the scale of destrucon of the links of the hemomicrocirculatory bed of the choroid of the eyeball of white rats and the specied changes naturally pass into the stage of irreversible ones.In addion, we noted a clear trend of growth in morphological changes in the structural elements of the choroid of the eye, the ndings were characterized by direct correlave relaonships with the duraon of the pathology, and, accordingly, the severity of the disease.Aer 6 weeks of the experiment, we found that the destrucon of the choroid of the eyeball was at the stage of morphological decompensaon, and the capillaries of the membrane underwent signicant destrucve perturbaons, while the arterioles acquired a tortuous structure, with impaired patency and uneven lumen.No less signicant were pathological deviaons of the capillary link of the ciliary processes, we observed frequent phenomena of capillary obliteraon, atrophic changes in the capillary component of the hemomicrocirculatory bed, and also idened fragments of individual capillaries completely deprived of their basic funcons.