Value of Serum Markers in Evaluating the Curative Effect of Immune Checkpoint Inhibitors for Lung Cancer

The changed levels of serum NSE, pro-GRP, Cyfra21-1, SCC, and CEA in the lung cancer patients in pre- and post-immunotherapy with ICIs were related to the therapeutic effect and may be used for the response evaluation. The SCLC patients should choose serum NSE, pro-GRP, and CEA for the response evaluation of ICIs immunotherapy, and the NSCLC patients should choose serum Cyfra21-1, SCC, and CEA.

Authors

Publication Details

Journal
Clinical Laboratory
Published
2025-01-01
DOI
https://doi.org/10.7754/clin.lab.2024.240432
Primary Topic
Cancer Immunotherapy and Biomarkers
Type
article
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article

Value of Serum Markers in Evaluating the Curative Effect of Immune Checkpoint Inhibitors for Lung Cancer

En-Dong Wu, Yan Chen, Yifeng Ma, Guangli Shi
Clinical Laboratory
Cancer Immunotherapy and Biomarkers
article

Value of Serum Markers in Evaluating the Curative Effect of Immune Checkpoint Inhibitors for Lung Cancer

En-Dong Wu, Yan Chen, Yifeng Ma, Guangli Shi
article en

Abstract

The changed levels of serum NSE, pro-GRP, Cyfra21-1, SCC, and CEA in the lung cancer patients in pre- and post-immunotherapy with ICIs were related to the therapeutic effect and may be used for the response evaluation. The SCLC patients should choose serum NSE, pro-GRP, and CEA for the response evaluation of ICIs immunotherapy, and the NSCLC patients should choose serum Cyfra21-1, SCC, and CEA.

Clinical LaboratoryVol. 71(07/2025)
Good health and well-being
Openalex Percentile: Top 74%
Cancer Immunotherapy and Biomarkers
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Value of Serum Markers in Evaluating the Curative Effect of Immune Checkpoint Inhibitors for Lung Cancer — En-Dong Wu, Yan Chen, et al. · Clinical Laboratory (2025) | TGRS Research Map | TGRS