New evidence for the effect of type 2 diabetes and glycemic traits on lung function: a Mendelian randomization and mediation analysis
This study validated the causal relationship between T2DM and decreased lung function, with smoking and SBP acting as mediators. This study provides a novel perspective on the occurrence and development mechanisms of reduced lung function as well as potential new targets for metabolic intervention in treatment.
Authors
- Wanlu Ma (ORCID: https://orcid.org/0000-0001-7363-4432)
- Yifan He (ORCID: https://orcid.org/0009-0006-5756-0166)
- Shuo Xie
- Fei Chen (ORCID: https://orcid.org/0000-0002-1244-2194)
- Xiaoping Chen (ORCID: https://orcid.org/0000-0002-5894-2661)
- Liping Yu
- Bo Zhang (ORCID: https://orcid.org/0000-0003-3060-7850)
- Lulu Song (ORCID: https://orcid.org/0000-0003-0705-8873)
- Ying Yang (ORCID: https://orcid.org/0009-0006-8248-2358)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China-Japan Friendship Hospital (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Clinics
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.clinsp.2025.100693
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China
- National Key Research and Development Program of China Stem Cell and Translational Research