Research Progress of SREBP in Ocular Disease

Sterol regulatory element-binding proteins (SREBP) is a class of transcription factor that regulate the metabolism of cholesterol, fatty acids and phospholipids and is widely expressed in body tissues. SREBP is known to play important roles in the physiological and pathological processes of metabolic diseases, cardiovascular diseases, tumors and other diseases. In recent years, the study of SREBP in ocular diseases has received extensive attention, and it has been shown that SREBP plays an important role in the development of diseases such as dry eye, diabetic retinopathy (DR), age-related macular degeneration (AMD), glaucoma, cataract, and retinoblastoma. SREBP affects the function of ocular tissues by regulating lipid metabolism, inflammation, oxidative stress, and apoptosis, and may be a novel therapeutic target for ocular diseases. This article summarizes the progress of SREBP in ocular diseases, focusing on its role in various ocular pathologies and its potential therapeutic value to provide new ideas for the prevention and treatment of related diseases.