Sweet Syndrome and Valley Fever: A Case Report

Sweet's syndrome, also referred to as erythema sweetobullosum, is a rare dermatologic condition that may serve as a clinical diagnostic clue in the emergency department (ED) for coccidioidomycosis, commonly known as Valley fever. This case describes a patient who presented with the acute onset of painful bullous lesions on the forearms, chest, and anterior legs. Recognition of these cutaneous findings as Sweet's syndrome, in conjunction with a high index of suspicion for Valley fever, led to the initiation of appropriate treatment with fluconazole and prednisone prior to the return of confirmatory coccidioidomycosis serologies. Early therapeutic intervention resulted in symptomatic improvement.