Synergistic effects of multiple pathological processes on Alzheimer's disease risk: Evidence for age-dependent stroke interactions
Cumulative pathological burden demonstrates a strong dose-response relationship with AD risk, significantly amplified by stroke history. The pronounced age-dependent effects highlight the need for age-specific prevention strategies, with particular emphasis on aggressive vascular risk management in younger populations. These findings support comprehensive pathological burden assessment for enhanced risk stratification and personalized dementia care approaches.
Authors
- Xinlei Xia (ORCID: https://orcid.org/0000-0002-3761-5004)
- Min Jiang (ORCID: https://orcid.org/0000-0001-5870-5634)
- Feng Liu (ORCID: https://orcid.org/0000-0003-3949-9067)
- Fen Liu (ORCID: https://orcid.org/0000-0001-9446-5340)
- Chengjie Zheng
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Henan University of Science and Technology (CN)
- Fujian Provincial Hospital (CN)
Publication Details
- Journal
- The Journal of Prevention of Alzheimer s Disease
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1016/j.tjpad.2025.100268
- Citations
- 1
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.84