MALAT1 overexpression contributes to choriocarcinoma by binding with RBM10 and promoting p53 degradation
In conclusion, our findings establish MALAT1 as a critical oncogenic driver in CC, functioning through its interaction with RBM10 to destabilize p53 and accelerate tumor progression. These insights highlight the potential of the MALAT1-RBM10-p53 axis as a therapeutic target in CC.
Authors
- Xiaohui Chen
- Hui Li (ORCID: https://orcid.org/0000-0001-7467-4823)
- Yan Feng (ORCID: https://orcid.org/0000-0002-6692-923X)
- Panhong Fan
Institutions
- Henan Provincial People's Hospital (CN)
Publication Details
- Journal
- Placenta
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1016/j.placenta.2025.07.075
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00