The diabetes gene Tcf7l2 organizes gene expression in the liver and regulates amino acid metabolism
Taken together, these data indicate that hepatic TCF7L2 has a secondary role in glycemic control, but a primary role in maintaining transcriptional architecture and glutamine homeostasis.
Authors
- Matt Kanke (ORCID: https://orcid.org/0000-0002-7227-3054)
- Pedro Henrique Vendramini (ORCID: https://orcid.org/0000-0001-9653-7248)
- William O’Connor
- Linus Tsai (ORCID: https://orcid.org/0000-0002-0134-6949)
- Sudha B. Biddinger (ORCID: https://orcid.org/0000-0002-2352-067X)
- Krishna G. Aragam (ORCID: https://orcid.org/0000-0003-3223-9131)
- Mareike Schell (ORCID: https://orcid.org/0000-0002-9999-445X)
- Ivana Semova (ORCID: https://orcid.org/0000-0002-9754-1940)
- Joanna Krawczyk (ORCID: https://orcid.org/0000-0001-8263-1890)
- Marcia C. Haigis (ORCID: https://orcid.org/0000-0003-2530-2681)
- Praveen Sethupathy
- Tiffany Fougeray
- G. Pengo
- Kiran J. Biddinger
- Wouter H. Lamers
Institutions
- Broad Institute (US)
- Boston Children's Hospital (US)
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Cornell University (US)
- Amsterdam UMC Location University of Amsterdam (NL)
- Massachusetts General Hospital (US)
- Boston VA Research Institute (US)
- University of Amsterdam (NL)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-07-16
- DOI
- https://doi.org/10.1016/j.molmet.2025.102208
- Citations
- 1
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- National Institutes of Health
- Boston Nutrition Obesity Research Center, Boston University
- Harvard Digestive Diseases Center, Harvard University