Diagnostic and prognostic relevance of RAF1 gene in acute myeloid leukemia
Acute Myeloid Leukemia (AML) demands precise diagnostic and prognostic tools for accurate detection and personalized-treatment strategies. Using Real-Time PCR, we investigated the RAF1, miR-146 b-3p, and Circ-RPL15 network expression in AML. Because RAF1 is a crucial gene involved in various ways, it is considered a potential biomarker for prognosis and diagnosis. While no significant correlation was found within the network, RAF1 expression showed a marked difference between groups. ROC curve analysis for RAF1 demonstrated promising diagnostic performance, and our bioinformatics investigations supported its strong prognostic potential. Identifying such biomarkers can aid in developing better management based on patients' characteristics.
Authors
- Mohammad Sayyadi (ORCID: https://orcid.org/0000-0003-2927-9669)
- Mohammad Rafiee (ORCID: https://orcid.org/0000-0001-5684-5756)
- Sina Rahimpour (ORCID: https://orcid.org/0009-0006-2333-112X)
- Seyedeh Zahra Shahrokhi (ORCID: https://orcid.org/0000-0002-2028-5918)
- Yasin Mirazimi (ORCID: https://orcid.org/0000-0002-5862-5893)
- Maryam Kargar (ORCID: https://orcid.org/0000-0001-7922-7942)
Institutions
- Hamedan University of Medical Sciences (IR)
- Zanjan University of Medical Sciences (IR)
- Arak University of Medical Sciences (IR)
- Aja University of Medical Sciences (IR)
- Shahid Beheshti University of Medical Sciences (IR)
Publication Details
- Journal
- Leukemia Research Reports
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.lrr.2025.100528
- Primary Topic
- Retinoids in leukemia and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Zanjan University of Medical Sciences