Beta-Klotho Protein Expression in Healthy Human Tissues and Liver Biopsies From Patients With MASLD or MASH
This study provides insight into target organs for FGF-based drugs and demonstrates that hepatic KLB remains expressed throughout MASLD stages, supporting the use of FGF-based drugs in early and advanced stages of MASLD.
Authors
- Cristy R.C. Verzijl (ORCID: https://orcid.org/0000-0002-8359-0370)
- Roos E. Eilers
- Johan W. Jonker (ORCID: https://orcid.org/0000-0002-3919-5437)
- Max Nieuwdorp (ORCID: https://orcid.org/0000-0002-1926-7659)
- Joanne Verheij (ORCID: https://orcid.org/0000-0003-1283-630X)
- Stan Driessen (ORCID: https://orcid.org/0000-0003-1485-9732)
- Dicky Struik
- Adriaan Georgius Holleboom (ORCID: https://orcid.org/0000-0002-2911-2917)
- Justina C. Wolters (ORCID: https://orcid.org/0000-0003-0066-3720)
- Alexandra Aaldijk (ORCID: https://orcid.org/0000-0001-8737-7916)
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Gastro Hep Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.gastha.2025.100745
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health~Holland
- ZonMw
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Maag Lever Darm Stichting
- Merck Sharp and Dohme
- HORIZON EUROPE Framework Programme