An Open-Source Browser-Based Nonlinear Model Predictive Controller for Type 1 Diabetes

We provide an open-source implementation of the NMPC algorithm for closed-loop insulin therapy presented by Hovorka et. al. in the seminal paper from 2004. An extended Kalman filter is added as observer, since specifics on state estimation have been omitted in the original paper. The controller is now part of the TypeScript-based closed-loop diabetes simulator LT1, which also comprises a library of models describing CGM sensors, infusion pumps, and patient physiology. The controller can thus be extensively tested in various closed-loop configurations. Also, the graphical user interface enables its integration in educational tools.