HISTONE LACTYLATION IN IMMUNE CELLS AND ITS PREDICTIVE ROLE IN SEPSIS PROGRESSION: A PROSPECTIVE OBSERVATIONAL STUDY
Immune cell lactylation may serve as a biomarker for sepsis progression. The combination of neutrophil H4K5la and CRP enhances early diagnostic accuracy; reduced lactylation on day 3 may indicate poor prognosis.
Authors
- Lihua Chu (ORCID: https://orcid.org/0000-0002-6664-279X)
- Xiangming Fang (ORCID: https://orcid.org/0000-0001-9922-8977)
- Shuang Song (ORCID: https://orcid.org/0000-0002-8550-6320)
- Guohao Xie (ORCID: https://orcid.org/0000-0001-9793-021X)
- Yuqian Guo
- Huiyi Hu (ORCID: https://orcid.org/0000-0002-4398-5167)
- Wei Shui (ORCID: https://orcid.org/0000-0002-9198-4783)
- Dongdong Wang (ORCID: https://orcid.org/0000-0001-5143-3947)
- Liman Hao
Institutions
- Shaoxing City Women and Children Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
Publication Details
- Journal
- Shock
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1097/shk.0000000000002659
- Citations
- 3
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.06