Improvement of recalcitrant multisystem disease in dermatomyositis with anifrolumab: a case series

This case series is the first to demonstrate anifrolumab's potential to treat refractory extracutaneous manifestations of adult-onset DM, facilitate prednisone tapering and discontinue systemic therapies. These findings provide new evidence that systemic blockade of type I interferon can manage treatment-resistant multi-organ DM manifestations, including skin, joint and muscle involvement.