Fetal Defects in Mice Treated With Integrase Strand Transfer Inhibitors: Comparison of Dolutegravir, Raltegravir, Bictegravir, and Cabotegravir
While INSTIs represent a critical advance in the management of HIV infection, the findings of the current study demonstrate a link between INSTI therapy and adverse fetal outcomes. This highlights the need for continued surveillance of pregnancy outcomes in women exposed to INSTIs.
Authors
- Evelyn Yukino Laurette (ORCID: https://orcid.org/0009-0004-3405-0345)
- Andrew J. Copp (ORCID: https://orcid.org/0000-0002-2544-9117)
- Oscar Tejada (ORCID: https://orcid.org/0000-0002-4831-1372)
- Haneesha Mohan (ORCID: https://orcid.org/0000-0003-4132-8363)
- Lena Serghides (ORCID: https://orcid.org/0000-0002-2817-6134)
- Jessica Nguyen (ORCID: https://orcid.org/0000-0002-1889-305X)
- Jennifer Jao
- Tanvi Sanghvi
- Nicholas D. E. Greene (ORCID: https://orcid.org/0000-0002-4170-5248)
- John G. Sled (ORCID: https://orcid.org/0000-0002-4461-283X)
- Audrey Yee
Institutions
- Northwestern University (US)
- University Health Network (CA)
- University of Toronto (CA)
- Great Ormond Street Hospital (GB)
- Hospital for Sick Children (CA)
- Toronto General Hospital (CA)
- University College London (GB)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-07-04
- DOI
- https://doi.org/10.1093/infdis/jiaf362
- Citations
- 2
- Primary Topic
- HIV/AIDS drug development and treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.79