Macrophage-derived exosome piR-50971 exacerbates sepsis-induced myocardial injury by inhibiting autophagy through the upregulation of N6-Methyladenosine modification of mTOR
Our findings reveal a novel mechanism by which macrophage-derived exosome piR-50971 contributes to SIMI by suppressing autophagy via m<sup>6</sup>A modification of mTOR. Overall, our results implicate piR-50971 as a potential target for therapeutic intervention in sepsis-related myocardial dysfunction.
Authors
- Yunsheng Chen (ORCID: https://orcid.org/0000-0002-2086-9833)
- Min Gao (ORCID: https://orcid.org/0000-0002-0001-5283)
- Hanting Zhu
- Shan Zhong (ORCID: https://orcid.org/0000-0001-5871-3634)
- Jiarong Yu (ORCID: https://orcid.org/0000-0001-6105-7615)
- Juan Wang (ORCID: https://orcid.org/0009-0000-1801-0045)
- H. F. Liu (ORCID: https://orcid.org/0009-0003-8666-5870)
- Wang Jia-qiang (ORCID: https://orcid.org/0000-0002-5979-3039)
- Jie Zhang (ORCID: https://orcid.org/0000-0001-8831-7464)
- Xuelian Chen (ORCID: https://orcid.org/0000-0001-9051-0802)
- Yan Liu (ORCID: https://orcid.org/0000-0002-4000-1273)
- Xiong Zhang (ORCID: https://orcid.org/0000-0002-3749-4206)
- Chenghao Lu
Institutions
- Ruijin Hospital (CN)
Publication Details
- Journal
- Burns & Trauma
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/burnst/tkaf045
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China