Computational Design of Drugs for Epilepsy using a Novel Guided Evolutionary Algorithm for Enhanced Blood Brain Barrier Permeability
Guided evolution is an efficient computational approach for the design of CNS drugs. The de novo design of drugs by application of the guided evolution algorithm, developed as part of this work, has resulted in the generation of ligands that are potential drugs for the cure of epilepsy. However, the effectiveness of these drugs for the cure of epilepsy has to be validated experimentally.
Authors
- Sekhar Talluri (ORCID: https://orcid.org/0000-0002-3394-9795)
Institutions
- GITAM University (IN)
Publication Details
- Journal
- Central Nervous System Agents in Medicinal Chemistry
- Published
- 2025-07-14
- DOI
- https://doi.org/10.2174/0118715249385792250709073502
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00