The Potential Mechanisms of Banxia Xiexin Decoction in Treating Chronic Colitis: Insights from UPLC-Q-TOF-MS/MS and Network PharmacologyStudies
Quercetin, kaempferol, baicalein, and naringenin, the main active ingredients in BXD, may play roles in anti-inflammatory, antimicrobial, and regulating intestinal microbiota to achieve the therapeutic purpose of CC treatment by mediating the targets of AKT1, IL-6, TP53, and ALB, and regulating the signaling pathways of IL-17, TNF, and PI3K-Akt.
Authors
- Mengyuan Wang
- Chunli Gan (ORCID: https://orcid.org/0000-0003-2235-745X)
- Xinyao Pan
- Chunjuan Yang (ORCID: https://orcid.org/0000-0001-9221-7167)
- Jinhui Wang (ORCID: https://orcid.org/0000-0001-8340-717X)
- Ruyun Zhang (ORCID: https://orcid.org/0000-0002-4932-7536)
Institutions
- Harbin Medical University (CN)
Publication Details
- Journal
- Combinatorial Chemistry & High Throughput Screening
- Published
- 2025-07-14
- DOI
- https://doi.org/10.2174/0113862073350796250305225907
- Citations
- 2
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 3.11