Clinical and Sonographic Assessment of Carboxytherapy Efficacy in Treatment of Skin Aging: A 2-split Randomized Clinical Trial.

Twenty-eight patients with skin-intrinsic aging manifestations in the abdomen completed the study. Their mean age was 44.13 years. The mean weight, BMI, and waist circumference of the subjects significantly decreased after the treatment. The clinical subjective and objective evaluations revealed statistically significant improvement of skin wrinkles, laxity, and skin pigmentation and overall satisfaction by carboxytherapy. Upon sonographic investigation, a significant increase in epidermis and dermis thickness was observed. No significant side-effect was reported by the subjects.