Licorice extract and carbenoxolone protect PC12 cells against serum/glucose deprivation-induced apoptosis through modulation of caspase-3 and PARP activation.
Taken together, this study confirms the protective and free radical-scavenging potency of licorice extract and carbenoxolone in <i>in vitro</i> model of ischemia. Overall, it seems that pretreatment with the licorice extract and carbenoxolone may potentially slow the progression of brain ischemia.
Authors
- Hossein Hosseinzadeh (ORCID: https://orcid.org/0000-0002-3483-851X)
- Elham Ramazani (ORCID: https://orcid.org/0000-0003-1874-6911)
- Zahra Tayarani‐Najaran (ORCID: https://orcid.org/0000-0001-8899-0886)
- Soheyla Bakhshi
Institutions
- Yazd University (IR)
- Mashhad University of Medical Sciences (IR)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- DOI
- https://doi.org/10.22038/ajp.2024.25252
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Mashhad University of Medical Sciences