Evidence-based guideline diagnosis, treatment, prevention and aftercare of oropharyngeal and hypopharyngeal carcinoma
The guideline is being drawn up as a joint guideline for oropharyngeal and hypopharyngeal carcinoma. Oropharyngeal carcinoma in particular has experienced the greatest increase in incidence among all head and neck carcinomas in the last 20 years and is now the sixth most common cancer in men in Germany. Together with hypopharyngeal carcinoma, these tumors are currently the most common cancer entity in the head and neck region. Due to the association with human papillomavirus type 16 (HPV16), we now distinguish two groups of oropharyngeal carcinomas in Germany: HPV16-positive (approx. 35%) and HPV-negative (approx. 65%). A HPV16 association with hypopharyngeal carcinoma has not been described. The therapy covers the entire spectrum of head and neck surgery, including diversified reconstructive procedures, transoral and external approaches, the options for primary and adjuvant radiotherapy (possibly in combination with chemotherapy) and the current recommendations for drug-based tumor therapy, which range from classic chemotherapy to immuno-oncology. In addition, measures for early detection and prevention are carried out, with particular consideration of the HPV16-associated genesis of oropharyngeal carcinoma, as well as adequate rehabilitation after the primary treatment of oropharyngeal and hypopharyngeal carcinomas. Finally, the treatment options for recurrences or distant metastases that cannot be cured in the further course of the disease are shown and classified.
Authors
- Bernd Lethaus (ORCID: https://orcid.org/0000-0002-9619-9362)
- Peter Brossart
- Imad Maatouk (ORCID: https://orcid.org/0000-0002-8030-1182)
- Klaus Zöphel (ORCID: https://orcid.org/0000-0002-7587-2386)
- Thomas Langer (ORCID: https://orcid.org/0000-0003-1250-1462)
- Thomas Hoffmann (ORCID: https://orcid.org/0000-0002-2980-8324)
- Christian Duncker (ORCID: https://orcid.org/0000-0001-6306-3269)
- Kerstin Paradies
- Günther Klautke
- Wilko Weichert (ORCID: https://orcid.org/0000-0001-6139-8372)
- Susanne Singer (ORCID: https://orcid.org/0000-0001-5784-7964)
- Michael Fuchs (ORCID: https://orcid.org/0000-0003-1147-065X)
- Annerose Keilmann (ORCID: https://orcid.org/0000-0002-4210-9122)
- Monika Nothacker (ORCID: https://orcid.org/0000-0003-4928-7391)
- Stephan Lang (ORCID: https://orcid.org/0009-0000-4420-9664)
- Kathy Taylor
- Herbert Hellmund
- Jochen Heß (ORCID: https://orcid.org/0000-0003-3493-1711)
- A. Relic
- Oliver Bayer (ORCID: https://orcid.org/0000-0003-4648-9481)
- Peter Jens Klußmann
- Panagiotis Balermpas (ORCID: https://orcid.org/0000-0001-5261-6446)
- Markus Follmann
- Kristina Lippach
- Georg Maschmeyer (ORCID: https://orcid.org/0000-0003-2378-2466)
- Orlando Guntinas‐Lichius (ORCID: https://orcid.org/0000-0001-9671-0784)
- M Steingraber
- G. L. Kissinger
- Tim Waterboer (ORCID: https://orcid.org/0000-0002-0616-6963)
- Michael Lell (ORCID: https://orcid.org/0000-0002-4800-4428)
- Susanne Wiegand (ORCID: https://orcid.org/0000-0003-1183-9226)
- Kerstin Schmidt (ORCID: https://orcid.org/0000-0002-9596-4026)
- Hans Christiansen (ORCID: https://orcid.org/0000-0002-0960-7955)
- Andreas Dietz (ORCID: https://orcid.org/0000-0001-8254-1676)
- Jan D. Raguse
- Wilfried Budach
- Jens Büntzel
- Fritz Sterr
- Havva Cici
- Jutta Yzer
Institutions
- University of Bonn (DE)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Hospital Bonn (DE)
- Association of the Scientific Medical Societies (DE)
- University Hospital Heidelberg (DE)
- University Hospital of Basel (CH)
- Universitätsklinik für Hals-, Nasen- und Ohrenkrankheiten (AT)
- Düsseldorf University Hospital (DE)
- Institut für Medizinische Biometrie, Informatik und Epidemiologie (DE)
- Augenklinik Universitätsklinikum Würzburg (DE)
- Nuremberg Hospital (DE)
- Klinik und Poliklinik für Nuklearmedizin (DE)
- German Cancer Society (DE)
- PHV Dialysezentrum (DE)
- Klinik und Poliklinik für Strahlentherapie und Radioonkologie (DE)
- Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie (DE)
- Deutsche Schmerzgesellschaft (DE)
- München Klinik (DE)
- Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde (DE)
- Pathologie Hamburg-West (DE)
- Praxis für Humangenetik (DE)
- Südharz Klinikum (DE)
- Evangelisches Diakoniekrankenhaus (DE)
- Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie (DE)
- DIAKO (DE)
- Orthopädische Praxis (DE)
- Fachklinik Hornheide (DE)
- Klinikum Chemnitz (DE)
- Nuklearmedizinische Klinik des Klinikums rechts der Isar (DE)
- Heinrich Heine University Düsseldorf (DE)
- Praxis (EE)
- Leipzig University (DE)
Publication Details
- Journal
- PubMed
- Published
- 2025-06-24
- DOI
- https://doi.org/10.3205/000339
- Citations
- 1
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.85