Informative value of calculated indices of liver steatosis in patients with non-alcoholic fatty liver disease and postmenopausal obesity

The aim. to study the diagnostic characteristics of liver steatosis assessment indices in patients with non-alcoholic fatty liver disease (NAFLD) and postmenopausal obesity. Materials and methods. 88 postmenopausal women were examined, of whom 70 with an average age of 51.0 (49.0-52.0) years had NAFLD and pre-obesity/obesity and 18 with an average age of 50.5 (48.0-51.0) years without obesity and liver pathology. Waist size was measured in all women, body mass index was calculated, the level of transaminases, gamma-glutamyltranspeptidase and triglycerides were determined, and the steatosis indices HSI (Hepatic steatosis index) and FLI (Fatty liver index) were calculated. Verification of liver steatosis was performed by ultrasound examination. The ROC curve method was used to determine the threshold values and calculate the diagnostic characteristics of the models. Results. During the ROC analysis, the threshold value of the HSI index in patients with NAFLD was 30.5 with sensitivity and specificity of 98.5% and 97.3%, respectively. The predictor value of the FLI index for determining the risk of steatosis in this risk group was 35 (sensitivity 72.2%, specificity 100%). Conclusion. The calculated HSI and FLI indices are quite informative methods for diagnosing a high risk of steatosis in women with pre-obesity and postmenopausal obesity.