Differential diagnostic value of serum leptin level and polymorphism of the leptin receptor gene Gln223Arg in metabolic fatty and alcoholic liver diseases

The aim of the investigation is the study of the serum leptin content and polymorphism of the leptin receptor gene glutamine 223 arginine (LEPR Gln223Arg ) as additional criteria for the differential diagnosis of metabolic and alcoholic liver diseases. The subject of the study: serum leptin content and polymorphism of the leptin receptor gene LEPR Gln223Arg in patients with metabolic fatty liver disease and alcoholic liver disease. The investigation methods. A comparative analysis of the serum leptin level and polymorphism of the leptin receptor gene LEPR Gln223Arg was carried out in 108 patients with metabolic fatty liver disease and in 80 patients with alcoholic liver disease with an assessment of body mass index, lipid metabolism, and gender differences. Results. Reliable differences in serum leptin content and the frequency of genotypes of the leptin receptor gene LEPR Gln223Arg were revealed in patients with metabolic fatty liver disease and alcoholic liver disease. The results obtained can serve as additional differential diagnostic criteria between metabolic fatty liver disease and alcoholic liver disease in the early stages. Conclusion. The results obtained confirm hyperleptinemia in patients with metabolic fatty liver disease exceeding that in patients with alcoholic liver disease. Leptin resistance in men and women with metabolic fatty liver disease is associated with different genotypes of the leptin receptor gene LEPR Gln223Arg . No similar association of the genotypes of the leptin receptor gene LEPR Gln223Arg was found in patients with alcoholic liver disease.