Biodegradable Implantable Drug Delivery System

Conventional drug delivery routes are commonly used due to their ease of administration and systemic effects. However, they present significant limitations such as hepatic firstpass metabolism, gastrointestinal degradation, hypersensitivity reactions, low bioavailability, and fluctuating plasma drug levels. These drawbacks reduce patient compliance, especially in chronic therapies. To address these issues, implantable polymeric drug delivery systems offer controlled and sustained drug release from devices implanted in the body. While non-biodegradable implants require surgical removal and show poor compatibility with water-soluble or highly ionized drugs and macromolecules, biodegradable systems overcome these challenges. They degrade within the body via enzymatic or chemical processes, eliminating the need for removal and enabling better release control. Recent advances include shape memory-based implants, 3D-printed systems, biosensor integration, real-time monitoring, and personalized medicine, further enhancing the efficiency and precision of drug delivery.