Pancytopenia with Kaposi’s Varicelliform Eruption and Oral Erosions in a Patient of Psoriasis Receiving Long Term Methotrexate for Psoriasis: A Rare Case Report

Methotrexate is an oral folic acid antagonist used in treatment of many dermatological diseases. It has varied side effects which may occur due to increased binding of drug to dihydrofolate reductase enzyme owing to its increased plasma concentration which may occur either due to drug overdose or drug interactions. Some of these adverse effects like pancytopenia are life threatening hence care should be taken while prescribing these drugs. Here we present an interesting case of methotrexate toxicity culminating in pancytopenia with KVE which occurred due to interaction with NSAIDs used concomitantly.