Spatial Proximity of Immune Cell Pairs to Cancer Cells in the Tumor Microenvironment as Biomarkers for Patient Stratification
RD-scores offer a spatially informed biomarker that outperforms traditional metrics in predicting survival and treatment response. This approach provides a new perspective on immune cell behavior in the TME and has potential utility in guiding personalized cancer therapies and patient stratification.
Authors
- Yanding Zhao (ORCID: https://orcid.org/0000-0002-6882-4888)
- Yanhong Liu (ORCID: https://orcid.org/0000-0002-6747-6834)
- Chao Cheng (ORCID: https://orcid.org/0000-0002-5002-3417)
- Yong Li (ORCID: https://orcid.org/0000-0001-8838-1714)
- Jiànróng Lǐ (ORCID: https://orcid.org/0000-0002-7130-1084)
- Yupei Lin (ORCID: https://orcid.org/0000-0001-7581-0663)
- Xingxin Pan (ORCID: https://orcid.org/0000-0002-4429-4878)
- Christopher I. Amos
Institutions
- Baylor College of Medicine (US)
- Houston Institute for Clinical Research (US)
- New Mexico Cancer Center (US)
- Stanford University (US)
Publication Details
- Journal
- Cancers
- Published
- 2025-07-14
- DOI
- https://doi.org/10.3390/cancers17142335
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cancer Prevention and Research Institute of Texas
- National Cancer Institute