Effect of the Combination of Tympanic Paracentesis and Intratympanic Hadocort-D Application on Otitis Media with Effusion in Adults

Background and Aim: The prevalence of otitis media with effusion in adults (OME) is very low, however, if it became chronic otitis media with effusion, it may affect the quality of life due to hearing loss and aural fullness. Therefore, early and proper management is essential. The aim of this study was to evaluate the effect of the combination of tympanic paracentesis and intratympanic Hadocort-D application for otitis media with effusion in adult. Materials and Methods: In total, 40 patients with otitis media with effusion that last for less than 2 months and had more than 4 times of tympanic paracentesis were included. They were randomly divided into two groups; the study group and control group. In study group, 20 patients (25 ears) had intratympanic Hadocort-D (Neomycin 75 000IU, Dexamethason mg, Xylometazolin hydroclorid 7.5 mg, Vietnam) application after tympanic paracentesis, and in control group, 20 patients (23 ears) had only tympanic paracentesis. We used tympanometry to confirm the middle ear effusion and pure tone audiometry to determine hearing threshold. Results: The intratympanic Hadocort-D application after tympanic paracentesis group produced better outcomes (22 ears, 88.0%) than the simple paracentesis group (11 ears, 47.8%). The recurrent rate was 12% (3 ears) in the study group, which was significantly lower than 39.1% (9 ears) of control group. Conclusion: The intratympanic Hadocort-D application after tympanic paracentesis on otitis media with effusion can reduce the number of repetitive procedures of tympanic paracentesis and prevent insertion of the ventilation tube and its short-term and long-term complications. Thus, its use in management of OME is recommended.