Vulnerability factors for pediatric disorders of gut–brain interaction and implications for functional impairment
Results support the biopsychosocial model suggesting that patients with p-DGBI are inherently susceptible to developing chronic pain due to biologic vulnerabilities and environmental factors. While infections remain the most reported trigger of p-DGBI symptoms, this study newly identifies other triggers. The association of increased number of vulnerability factors with worse functioning raises the question if there may be a cumulative adverse effect of multiple vulnerability factors.
Authors
- Samuel Nurko (ORCID: https://orcid.org/0000-0003-0936-4807)
- Bobbie Riley (ORCID: https://orcid.org/0000-0001-6883-7577)
- Enju Liu
- Hannah Brewer
- Beate C. Beinvogl (ORCID: https://orcid.org/0000-0001-9303-3474)
- Elizabeth Burch (ORCID: https://orcid.org/0000-0002-9780-7219)
- Amy E. Hale (ORCID: https://orcid.org/0000-0002-9346-7261)
- Julie Snyder (ORCID: https://orcid.org/0000-0002-0889-2803)
- Neil L. Schechter (ORCID: https://orcid.org/0009-0009-0176-652X)
Institutions
- Boston Children's Hospital (US)
- Shriners Hospitals for Children - Boston (US)
Publication Details
- Journal
- Journal of Pediatric Gastroenterology and Nutrition
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1002/jpn3.70155
- Citations
- 1
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.81