Scorpion venom heat‐resistant synthetic peptide improves cognitive dysfunction of APP/PS1 mice through microglial retromer complex
Our findings suggest that SVHRSP may enhance microglial phagocytosis by modulating retromer complex activity, thereby alleviating Aβ accumulation and improving cognitive dysfunction in AD.
Authors
- Qi‐Fa Li
- Jia He (ORCID: https://orcid.org/0000-0002-6195-1462)
- Yaping Wu (ORCID: https://orcid.org/0000-0002-2979-5332)
- Ao‐Ran Sui (ORCID: https://orcid.org/0009-0006-3205-0944)
- Shao Li (ORCID: https://orcid.org/0000-0002-4889-8636)
- Yue‐Lin Huang
- Baojian Zhu
- Song‐Yu Guo
- Xiaogang Zhang (ORCID: https://orcid.org/0009-0002-6634-9267)
- Yue Kong
- Jie Zhao (ORCID: https://orcid.org/0000-0003-3760-4038)
- Hua Piao (ORCID: https://orcid.org/0000-0002-2702-0584)
- Na‐Na Hu
- Yue Zhang (ORCID: https://orcid.org/0000-0002-7786-0231)
Institutions
- Beijing Tongren Hospital (CN)
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
- Capital Medical University (CN)
- Dalian Medical University (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1111/bph.70124
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Natural Science Foundation of China
- Department of Education of Liaoning Province