Revolutionizing drug formulation: Advanced approaches for enhancing solubility

This article is done deliberately to easily understand the concepts of solubility enhancement techniques with their diagrammatic representation. Nowadays, newer potent drugs are facing solubility issues, which is a challenging aspect in the pharmaceutical industry. Many efficacious drugs are not able to reach the market due to their low solubilisation factor, and this creates a negative impact in the pharmaceutical field. Here, we have focused on the major techniques for solubility enhancement such as Particle size reduction, Lipophilicity of the drug,Cosolvency, Sonocrystallization, Nanonization, pH adjustment of the drug, hydrotrophy, salt formation which helps to improve rate of absorption, bioavailability, Dissolution rate and permeability of the newer poor water-soluble drugs.