Brahmidin: Canine defence against infections and inflammation

Wound infections and delayed healing are common challenges in veterinary care, particularly in canines. Conventional treatments, such as ointments and gels, often suffer from poor adhesion, frequent reapplication, and inconsistent drug delivery. To address these limitations, a spray adhesive patch was formulated using Curcuma longa (Turmeric), Azadirachta indica (Neem oil), and Centella asiatica, recognized for their antimicrobial, anti-inflammatory, and woundhealing properties in animal care.The formulation utilized bioethanol for improved drying control, ethyl cellulose for enhanced film formation, and a carefully balanced combination of glycerin and isopropyl myristate to prevent excessive stickiness and penetration. The spray was evaluated for spray uniformity, drying time, film adhesion, and stability, all of which met optimal standards for canine application. In-vitro diffusion studies confirmed controlled and sustained drug release, while the antimicrobial assay demonstrated a significant zone of inhibition against bacterial strains affecting canines. Additionally, an antiinflammatory assay validated the formulation’s ability to inhibit protein denaturation, supporting its efficacy in reducing inflammation and promoting wound healing.The optimized spray adhesive patch exhibited fast drying, strong adhesion, and enhanced therapeutic effects, making it a promising solution for efficient and effective canine wound management.