Formulation and evaluation of nanoemulsion for topical drug delivery system

This study centers on the thorough assessment of optimal curcumin-loaded nanoemulsion formulations designed for improved topical administration. We extensively looked at important physicochemical factors such globule size, polydispersity index (PDI), pH, refractive index (RI), viscosity, and zeta potential. B3 had the smallest globule size (78.03 nm) and the lowest PDI (0.13) of all the formulations evaluated. This means that the dispersion was steady and uniform. Transmission electron microscopy corroborated spherical shape in alignment with particle size measurements. In vitro drug release experiments showed a sustained release profile, with formulation B3 having the maximum curcumin release (98.12% over 24 hours). Tests of stability at varied temperatures and humidity levels indicated that the droplet size, PDI, and other metrics changed very little over 90 days, which shows that the formulation is strong. These results indicate that formulation B3 is a good choice for stable and effective topical administration of curcumin.