Coordinated Expression of BMP10/ALK1/endoglin—Proteins that Drive Embryonic Cardiac and Vascular Morphogenesis—in Patients with Heart Failure: The EMPEROR Program
The coordinated circulating expression of proteins critical to foetal cardiac and vascular development tracks closely with the severity of heart failure, as reflected by symptoms, cardiac injury and stress, prevalence of atrial fibrillation and other comorbidities, and prognosis, suggesting a role of BMP10/ALK1/endoglin signalling in the progression of heart failure.
Authors
- Tariq Jamal Siddiqi
- Milton Packer
- Mikhail Sumin (ORCID: https://orcid.org/0000-0002-3827-5793)
- Javed Butler (ORCID: https://orcid.org/0000-0001-7683-4720)
- Sandra González Maldonado
- James Louis Januzzi (ORCID: https://orcid.org/0000-0002-8338-1798)
- Jürgen H. Prochaska (ORCID: https://orcid.org/0000-0001-5078-9992)
- Marina Panova‐Noeva (ORCID: https://orcid.org/0000-0003-2155-8030)
- Serge Masson (ORCID: https://orcid.org/0000-0002-1446-0281)
- João Pedro Ferreira (ORCID: https://orcid.org/0000-0002-2304-6138)
- Stefan D. Anker (ORCID: https://orcid.org/0000-0003-3331-7314)
- Stuart J. Pocock
- Faïez Zannad
Institutions
- Roche (Switzerland) (CH)
- University of London (GB)
- Boehringer Ingelheim (Germany) (DE)
- Harvard University (US)
- Inserm (FR)
- Universidade do Porto (PT)
- Johannes Gutenberg University Mainz (DE)
- National and Kapodistrian University of Athens (GR)
- Baylor University Medical Center (US)
- Jackson Memorial Hospital (US)
- University of Mississippi Medical Center (US)
- University of Mississippi (US)
- Massachusetts General Hospital (US)
- London School of Hygiene & Tropical Medicine (GB)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Baylor Medical Center at Garland (US)
- Berlin-Brandenburger Centrum für Regenerative Therapien (DE)
- German Centre for Cardiovascular Research (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Boehringer Ingelheim (China) (CN)
- Roth and Rau (Germany) (DE)
- Research Institute of Dallas (US)
- French Clinical Research Infrastructure Network (FR)
- Imperial College London (GB)
- University of Glasgow (GB)
- Université de Lorraine (FR)
Publication Details
- Journal
- European Journal of Heart Failure
- Published
- 2025-07-14
- DOI
- https://doi.org/10.1002/ejhf.3764
- Citations
- 1
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Eli Lilly and Company